Effect of Extract of Acanthopanax Senticosus Fruit on Breast Cancer Cells

Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of water extract senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231).Methods: The MTT assay was to assess proliferation. expression apoptosis-related genes assessed by quantitative real-time PCR.Results: ASF treatment caused dose-dependent inhibition growth both estrogen-independent MDA-MB-231 estrogen-dependent MCF-7 cells. decreased mRNA apoptotic suppressor gene Bcl-xL, increased proapoptotic genes. p21 RIP-1 types. survivin line.Conclusions: exhibits activity involving death.